2023年2月，英国《感染学杂志（Journal of Infection）》发布了一项东谈主群生态学策划论文——《肺孢子虫肺炎发病率有所飞腾》。这是由国王学院病院NHS基金会（King's College Hospital NHS Foundation）的凯瑟琳.帕特斯（Katharine Pates）和吉姆斯坦.佩里塞尔尼斯（Jimstan Periselneris）等策划东谈主员开展的感染性萧索病流行学访问策划。

据报谈，肺孢子虫肺炎（PCP/Pneumocystis pneumonia）是一种契机性感染萧索病，在免疫功能低下的东谈主群中的发病率和损失率较高。通过访问策划以前10年中东谈主群PCP发病率，反应出该患者群的增长化和各样化。

调研小组对2012年4月至2022年3月技能的英国所有这个词PCP入院患者情况进行了流行病学策划，网罗推行包括：PCP发作情况、年岁、中位入院时候、性别和其他呼吸谈真菌感染并发情况，对照了2019年1月至2022年5月技能甲氧苄啶-磺胺甲恶唑用药的徒然量。

效果败露：2012/13年至2019/20年技能，PCP的发病率从2.2东谈主/10万东谈主增多到了4.5/10万东谈主（p<0.0001）。2020/21年下落到了2.7东谈主/10万东谈主，2021/22年又回升到了3.9东谈主/10万东谈主。PCP发作行为全因入院的比例和其他真菌感染发作的比例出现飞腾，年岁为75岁+的PCP患者的比例从14%增多到26%，中位入院时候为13.5天。甲氧苄啶-磺胺甲恶唑的徒然量从2.14×10万增多到2.74×10万个DDDS（轨则日剂量）。

论断高慢：PCP的发病率呈现回升，关于医疗保健系统而言将是一个要紧职守。亟需进一步策划PCP的潜在风险，以期更好地加强退缩甘休。

文件起首：https://www.researchgate.net/publication/368432499

Rising Incidence of Pneumocystis pneumonia: a population-level descriptive ecological study in England

February 2023 Journal of Infection 86(35)

Katharine Pates，Jimstan Periselneris

King's College Hospital NHS Foundation

Objectives: Pneumocystis pneumonia (PCP) is an opportunistic infection that causes significant morbidity and mortality in the immunocompromised population. This population is growing and diversifying, yet contemporary epidemiology is lacking. We investigated the population-level incidence of PCP over the past decade. Methods: We conducted a descriptive study of all hospital admissions in England from April 2012 to March 2022. PCP episodes, age, median length of stay, gender and episodes of other respiratory fungal infections were collected. Consumption of Trimethoprim-Sulfamethoxazole was obtained between January 2019 and May 2022. Results: The incidence of PCP increased from 2·2 to 4·5/100,000 population between 2012/13 and 2019/20 (p<0·0001). There was a drop in 2020/21 to 2·7/100,000 before returning to 3.9/100,000 in 2021/22. PCP episodes rose as a proportion of all-cause admissions as well as a proportion of episodes due to other fungal infections. The proportion of PCP patients aged 75+ increased from 14 to 26%. The median length of stay was 13.5 days. Consumption of Trimethoprim-Sulfamethoxazole increased from 2.14×100,000 to 2.74/100,000 defined daily doses. Conclusions: The incidence of PCP is rising rapidly and represents a significant burden to the healthcare system. Further study into who is at risk of PCP is needed to better determine who should be given prophylaxis.

asandfromiswho发布于：云南省声明：该文不雅点仅代表作家本东谈主，搜狐号系信息发布平台，搜狐仅提供信息存储空间处事。